Methods: The Target-Mediated Drug Disposition (TMDD) equations and the Quasi-Steady-State (QSS) approximation of these equations were extended to describe drugs that can bind to multiple targets. Purpose: To compare performance of Nonmem 7 FOCEI, IMP, IMPMAP, SAEM, and BAYES methods on the simulated example of a complex pharmacokinetic system with rich sampling, and to compare precision of Nonmem parameter estimates with those predicted by PFIM 3.2 optimal design software. Bias and Precision of Parameter Estimates: Comparison of Nonmem 7 Estimation Methods and PFIM 3.2 Predictions on the Example of Quasi-Steady-State Approximation of the Two-Target Target-Mediated Drug Disposition Model
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